Amitriptyline and cholinergic supersensitivity
نویسندگان
چکیده
منابع مشابه
Amitriptyline-induced supersensitivity of a central muscarinic mechanism: lithium blocks amitriptyline-induced supersensitivity.
Chronic treatment with amitriptyline produces dose-dependent super-sensitivity of a central muscarinic cholinergic mechanism involved in the regulation of core body temperature. The authors demonstrated that chronic treatment with lithium prevents the induction of this response. The potential clinical and theoretical significance of this finding is set forth.
متن کاملCold stress and cholinergic supersensitivity.
To the Editor: In the rat (adult male Sprague-Dawley) chronic forced swim stress (Dilsaver et al. 1986) and chronic inescapable footshock (Dilsaver and Alessi 1987) induce marked supersensitivity to the hypothermic effects of the muscarinic cholinergic agonist oxotremorine. These observations are consistent with a report that immobilization of 10 min duration activates the septohippocampal musc...
متن کاملBright light blocks amitriptyline-induced cholinoceptor supersensitivity.
Introduction thal et al., 1984). This syndrome reportedly Seasonal affective disorder (SAD) is a synresponds to daily treatment with 2-6 hr of drome marked by recurrent depressions that bright artificial light (Lewy et al. 1982; Rogenerally occur in the fall or winter (Rosensenthal et al. 1984, 1986; James et al. 1985; Wehr et al. 1986). Neurobiological mechanisms accounting for the efficacy of...
متن کاملChronic inescapable footshock produces cholinergic system supersensitivity.
Webb W, Campbell SS (1983): Relationships in sleep characteristics of identical and fraternal twins. Arch Gen Psychiatry 40: 10931095. Weissman MM, Gershon ES, Kidd KK, Prusoff BA, Leckman JF, Dibble E, Hamovit J, Thompson D, Pauls DL, Guroff JJ (1984): Psychiatric disorders in the relatives of probands with affective disorders. The Yale University-National Institute of Mental Health Collaborat...
متن کاملChronic treatment with amitriptyline produces supersensitivity to nicotine.
The authors used a thermoregulation paradigm to evaluate effects of amitriptyline (AMI) on the sensitivity of a nicotinic mechanism involved in the regulation of core temperature in rats. Treatment with this tricyclic was associated with a significant increase in the hypothermic response to nicotine. Supersensitivity persisted for a minimum of 7.5 days following the last dose of AMI, and a sign...
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ژورنال
عنوان ژورنال: Biological Psychiatry
سال: 1988
ISSN: 0006-3223
DOI: 10.1016/0006-3223(88)90096-0